A postdoctoral research associate / scholar position is available in the Washington University Pain Center at Washington University School of Medicine in St. Louis. Dr. Jose Moron-Concepcion is seeking a highly motivated individual to pursue studies focused on defining (1) the roles of glutamate receptors in the mechanisms underlying opioid-induced synaptic plasticity, and (2) the mechanisms underlying opioid dependence and relapse to drug-seeking behavior. The research program involves a combination of electrophysiological, behavioral models of drug dependence, live cell imaging and molecular-genetic approaches. This position also provides the opportunity to gain expertise in molecular physiology and the determination of the role of glutamate and ion channels in the mechanisms underlying opioid-induced synaptic plasticity. In addition, this project will allow the development of imaging skills with epifluorescence and confocal microscopy. The focus will be on the professional growth and development necessary to transition to an independently-funded faculty researcher.
The ideal candidate should hold a Ph.D. or M.D./Ph.D. degree, possess a strong background in cellular electrophysiology, particularly the field recordings and whole-cell voltage-clamp techniques, and the analyses of electrophysiological data. In addition, experience with behavioral animal models of dependence (conditioned place preference, i.v. self-admin, etc.) is highly desirable. Experience/publications using the whole-cell variation of the patch-clamp technique and behavioral models of drug dependence.
* Prior experience with surgical procedures in rodents for intracranial administration of drugs is preferred.
* Experience with fluorescent imaging in single cells with either or both epifluorescence microscopy and/or confocal microscopy preferred.
* Experience working with glutamate receptors (AMPAR, NMDAR, mGluARs) is preferred.
* Completed or currently completing post-doctoral fellowship position.
Salary will be based on NIH guidelines.
Applicant Special Instructions
Applicants should send a cover letter with a brief statement of research experience and interests along with curriculum vitae and three letters of recommendation to: Jose Moron-Concepcion, PhD, Associate Professor of Anesthesiology, Washington University School of Medicine; email@example.com
All qualified applicants will receive consideration for employment without regard to sex, race, ethnicity, protected veteran, or disability status.
Associate Principal Scientist – Pain & Migraine Neuroscience–PHA001254
Merck is a global health care leader with a diversified portfolio of prescription medicines, and vaccines, as well as animal health products. Today, we are building a new kind of healthcare company – one that is ready to help create a healthier future for all of us.
Our ability to excel depends on the integrity, knowledge, imagination, skill, diversity and teamwork of people like you. To this end, we strive to create an environment of mutual respect, encouragement and teamwork. As part of our global team, you’ll have the opportunity to collaborate with talented and dedicated colleagues while developing and expanding your career.
As a key member of the Pain & Migraine Disease Area Biology Department, the successful candidate will conduct experiments to support preclinical drug discovery efforts at different stages of development including target identification and validation, lead identification and lead optimization. As an individual contributor, the successful candidate will generate and integrate data from in vitro and in vivo experiments towards the discovery and validation of pharmacological mechanism of action, target engagement, pharmacodynamic, efficacy and safety biomarkers of drug candidates.The successful candidate will participate on/lead multidisciplinary teams aimed at identifying novel treatments for chronic pain and migraine. The successful candidate will demonstrate the behaviors, expertise, organization and technical capabilities to deliver success on discovery programs as well as executing on functional business plans and contributing to the development of departmental objectives.
• A strong track record of achievement and experience of working on discovery programs aimed at identifying novel treatments for chronic pain or related diseases.
Preferred Experience and Skills:
• Track record of high quality research in the pain field
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Job:Pharmacology – DPS
Job Title:Assoc Prin. Scientist, Pharmacology
Primary Location: NA-US-PA-West Point
Employee Status: Regular