Projet de post-doctorat

Postdoctoral Fellow Position at Western University – Musculoskeletal Health

A postdoctoral fellow position is available to work with Dr. Joy MacDermid (Physical Therapy, Western University) at the Hand and Upper Limb Centre Clinical Research Laboratory at St. Joseph’s Hospital, London, Ontario.

The research involves a series of coordinated clinical, and knowledge translation research activities that address distal radius fracture management to develop an evidence-based algorithm for initial care and optimizing of physical activity/bone health.

Candidates should have completed their PhD and must have a strong background/experience in musculoskeletal health, clinical research, and statistics. Excellent communication skills (written and oral) are required. A track record in publication is required. Experience in longitudinal data analysis and patient assessment is preferred.

START DATE: September 1, 2017 to March 31, 2018 (possibility of extension, depending on funding).

TO APPLY: Please submit your CV, three academic references, and a brief statement of research interests and future goals to Dr. Joy MacDermid via e-mail: jmacderm@uwo.ca by August 15, 2017.

Le Centre interdisciplinaire de recherche en réadaptation et intégration sociale (CIRRIS) est à la recherche d’un (e)

COORDONNATEUR / COORDONNATRICE DE LA RECHERCHE PARTENARIALE

Pour stimuler le développement de partenariats et soutenir la valorisation des produits de la recherche, tant avec l’entreprise privée qu’avec les organismes publics ou communautaires, le CIRRIS a créé en 2015 le Bureau de Partenariats et d’Innovation (BPI). Les actions du BPI permettent d’accélérer les initiatives d’innovation qu’elles soient technologiques ou sociales entre les chercheurs et leurs partenaires en maximisant les retombées de la recherche en solutions concrètes en réadaptation et intégration sociale.

Sous l’autorité hiérarchique de la directrice scientifique et l’autorité fonctionnelle de la chef de service du CIRRIS, le/la candidat(e) travaillera en collaboration avec les chercheurs, les employés du CIRRIS et les partenaires pour :

Tâches
1. Supporter les chercheurs dans l’identification de partenaires (industrie, secteur public, organismes communautaires, fondations) et du potentiel de partenariat provenant de leurs intérêts/expertises de recherche.
2. Identifier les programmes de financement pertinents pour les intérêts de recherche et soutenir la compréhension dans l’exploitation de ces programmes.
3. Faciliter et accélérer le processus de montage de projets en partenariat.
4. Faire suivi périodique des occasions de partenariat et des projets en cours avec chaque chercheur actif.
5. S’assurer du respect des engagements (livrables, échéancier, etc.) des projets.
6. Contribuer au développement d’outils de promotion des expertises de recherche du CIRRIS.
7. Offrir des ateliers sur la recherche en partenariat et la valorisation de la recherche pour les membres du CIRRIS (étudiants, chercheurs, professionnels)
8. Soutenir les démarches avec les instances officielles de valorisation de l’Université Laval (propriété intellectuelle, déclaration d’inventions et d’œuvres).

Compétences recherchées
• Expérience du milieu de la recherche acquise via une formation en recherche M.Sc./Ph.D. ou expérience équivalente acquise sur le marché du travail.
• Connaissances sur un ou plusieurs des milieux suivants :
o les organisations de recherche au Québec et au Canada;
o le milieu académique au Québec (universités, laboratoires, ministères, etc.) ;
o le milieu socio-économique (industriel, entreprises, filières, associations).
• Grandes qualités relationnelles afin d’initier le rapprochement des différents partenaires et d’orienter chacun en fonction de ses besoins et intérêts.
• Esprit de synthèse et de développement.
• Habilités de communication et en marketing institutionnel et de l’innovation (Atout).
• Autonomie, sens de l’organisation et initiative.
• Capacité à communiquer en français et en anglais (oral et par écrit).

Lieu de travail :
CIRRIS
525, boul. Wilfrid-Hamel Québec (Québec) G1M 2S8

REMARQUE : le/la coordonnateur / coordonnatrice) de la recherche partenariale devra rencontrer régulièrement les chercheurs et les partenaires. Dans le cadre de ses activités de suivi et de prospection, la personne devra assister à des conférences et à des rencontres de réseautage afin d’identifier des partenaires potentiels. Mobilité et disponibilité sont donc indispensables.

Type de travail : Temps complet (possibilité de temps partiel à discuter) Entrée en fonction souhaitée : 14 août 2017
Salaire : En fonction des qualifications et de l’expérience
Date limite pour soumettre votre candidature : Le 15 juin 2017

Faire parvenir votre curriculum vitae complet, une lettre de présentation ainsi que les noms et coordonnées de trois références à :

Lyne Kelly
Chef de service aux affaires administratives et scientifiques CIRRIS/CIUSSS-CN/IRDPQ
lyne.kelly@cirris.ulaval.ca

POSTE # 64644
Professeure, professeur, Département de réadaptation

 

DESCRIPTION DU POSTE

1. Enseignement aux 1er et 2e cycles dans des cours du continuum de formation en physiothérapie visant le
développement de l’expertise clinique. Les domaines de besoin en enseignement qui seront priorisés sont :
l’utilisation des formes d’énergie invasives et des technologies émergentes à des fins évaluatives et d’intervention en
physiothérapie ; le contrôle moteur et les approches novatrices d’intervention; les pratiques avancées en
physiothérapie.
2. Enseignement aux 2e et 3e cycles dans d’autres programmes;
3. Recherche autonome en physiothérapie ou dans des disciplines connexes;
4. Direction/supervision d’étudiants aux trois cycles (tutorat, direction de thèses de doctorat, de mémoires et
des projets de fin d’études de maîtrise);
5. Participation aux comités et différentes instances (pédagogiques et administratives) du Département de
réadaptation.

CRITÈRES DE SÉLECTION

6. Être détenteur d’un diplôme de 1er ou de 2e cycle en physiothérapie;
7. Être membre (ou éligible à le devenir) de l’Ordre professionnel de la physiothérapie du Québec et de l’Association
québécoise de la physiothérapie;
8. Être détenteur d’un diplôme de 3e cycle (Ph.D.) dans un domaine relié et/ou connexe à la réadaptation, ou être en
voie d’obtenir ce diplôme; détenir une formation postdoctorale est un atout;
9. Être apte à enseigner dans un ou plusieurs domaines de besoin du programme;
10. Avoir une expérience clinique en physiothérapie ou de recherche clinique en réadaptation;
11. Posséder des aptitudes à communiquer et à enseigner en français.

Entrée en fonction : 1er septembre 2017

CANDIDATURE

Les candidatures seront traitées dans la plus stricte confidentialité.
Les personnes intéressées à poser leur candidature doivent faire parvenir au plus tard le 1er juin 2017, leur curriculum vitae, une lettre fournissant le détail de leur expérience clinique, d’enseignement, leur recherche en cours, leurs intérêts futurs de recherche ainsi que le nom de trois répondantes ou répondants. Les candidat(e)s sont aussi invité(e)s à décrire dans cette lettre, leur contribution potentielle au programme de physiothérapie et au département de réadaptation de l’Université Laval. Le dossier de candidature doit être expédié à:

Madame Hélène Moffet, directrice
Département de réadaptation, Faculté de médecine, Université Laval 1050, avenue
de la Médecine, Québec (Québec) G1V 0A6
Téléphone : 418 656‐2131 poste 5588; Fax: 418‐656‐5476
Helene.Moffet@rea.ulaval.ca

«Valorisant la diversité, l’Université Laval invite toutes les personnes qualifiées à présenter leur candidature, en particulier les femmes, les membres de minorités visibles et ethniques, les autochtones et les personnes handicapées. La priorité sera toutefois accordée aux personnes ayant le statut de citoyen canadien ou de résident permanent».

 


ÉTUDIANT POSTDOCTORANT ou FELLOW

L’Unité de recherche en arthrose du Centre recherche du Centre hospitalier de l’Université de Montréal (CRCHUM) est à la recherche d’un étudiant postdoctorant ou fellow pour la conduite de recherches translationnelles à partir de cohortes d’individus arthrosiques provenant d’études cliniques et /ou observationnelles et longitudinales.

Les candidats doivent posséder une expérience de recherche pertinente en épidémiologie/biostatistique. Le candidat retenu recevra une bourse pour la première année avec possibilité de renouvellement pour une année supplémentaire.

Les candidats intéressés doivent soumettre leur curriculum vitae décrivant leurs réalisations en recherche et une liste complète de leurs publications accompagnées de trois lettres de recommandation, dont l’une provenant de leur directeur de recherche au Ph. D., à l’attention de Professeure Johanne Martel-Pelletier, Directrice, Unité de recherche en arthrose, à l’adresse électronique suivante: jm@martelpelletier.ca

 

Texas_Tech_University_Health_Sciences_Center_School_of_Medicine_406514

Texas Tech University Health Sciences Center, School of Medicine, Lubbock Texas.

Department of Pharmacology and Neuroscience, and Center of Excellence for Translational Neuroscience and Therapeutics (CTNT), invites applications for Post-doctoral position in the laboratory of Dr. Benamar (http://www.ttuhsc.edu/som/pharmacology/faculty/benamar.aspx).

We are seeking highly motivated candidates with a Ph.D degree in pharmacology or neuroscience. The candidate will join a NIH-funded laboratory focusing on pain/analgesia, and 2) neurobiological effects of drugs of abuse (e.g. opioids, cannabinoids). Desired qualifications include experience in behavioral animal models (pain, conditioned place preference, self administration). In addition experience with microdialysis, HPLC, and immunohistochemistry are highly desirable.

The candidate will also have the opportunity to collaborate with a growing group of neuroscience investigators (http://www.ttuhsc.edu/som/pharmacology/) and have access to imaging (e.g. multi-photon microscopy), molecular and behavioral cores.

TTUHSC is an autonomous university adjacent to Texas Tech University (TTU) with an excellent research infrastructure (http://www.ttuhsc.edu/research/Core_Facilities.aspx). The Department houses electrophysiology and behavioral cores. A newly developed Center of Excellence for Translational Neuroscience and Therapeutics (CTNT), which features a Grant Development Program for collaborative projects, serves to bridge basic science and clinical disciplines (http://www.ttuhsc.edu/ctnt/). Salary will be based in NIH guidelines.

Must submit application online at http://www.texastech.edu/careers and apply to requisition ID #3882BR

If you have any questions please contact Dr. Benamar: khalid.benamar@ttuhsc.edu
The TTUHSC is an Equal Opportunity/Affirmative Action/Veterans/Disability Employer

 

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Offre (2) de recherche POSTDOCTORALE en codirection académique-industrie en biologie cellulaire et immunologie du cancer colorectal

Groupe de recherche : Prs Fernand-Pierre Gendron, Philippe Sarret (direction académique) et Immune Biosolutions inc. (direction industrielle) ainsi que Pr Éric Marsault (collaborateur).

Lieu de travail : Institut de Pharmacologie de Sherbrooke (IPS) et Pavillon de recherche appliquée sur le Cancer (PRAC) de l’Université de Sherbrooke

Subvention : Fonds Merck Sharpe & Dohme de la Faculté de médecine et des sciences de la santé de l’Université de Sherbrooke, MITACS et Créneau Accord (MEIE)

Titre du projet : Élaboration d’une nouvelle génération d’anticorps anti-P2Y6R et anti-NTS1R pour le diagnostic et le traitement du cancer colorectal

Projet : Le cancer colorectal (CCR) est la deuxième cause de mortalité due au cancer au Canada. Malgré des années de recherche, ce cancer est encore mal diagnostiqué et les traitements utilisés manquent de sélectivité. Les récepteurs couplés aux protéines G (RCPGs) sont la cible d’environ 40% des médicaments actuellement disponibles et ont récemment été identifiés comme de nouvelles cibles dans le traitement des cancers. L’absence d’outils valides permettant d’identifier l’expression endogène des RCPGs ou encore de moduler sélectivement leurs activités a grandement ralenti l’utilisation de cette famille de récepteurs pour le diagnostic et le traitement des cancers, incluant le CCR. Ce projet vise donc à développer et valider une nouvelle approche basée sur l’utilisation de peptides macrocycliques comme épitopes conformationnels mimétiques (MEM) pour produire des anticorps fonctionnels contre deux récepteurs couplés aux protéines G (NTS1R et P2Y6R) d’intérêt dans le diagnostic et le traitement du CRC. Le chercheur postdoctoral, sous la co-supervision du Pr F.P. Gendron ou du Pr P. Sarret et de l’équipe de recherche de Immune Biosolutions (IBio), aura comme projet de participer au développement de ces nouveaux anticorps et à la validation biologique de ces nouveaux agents biologiques. Étant donné que les poulets sont distants génétiquement des mammifères, les chances de génération d’un anticorps contre un GPCR de mammifère en sont augmentées. Brièvement, les poulets seront immunisés avec différents peptides linéaires et conformationnels ciblant les RCPG identifiés. Les différents types d’anticorps générés seront alors isolés des jaunes d’œufs par des techniques conventionnelles de chromatographie et de purification par immuno-affinité. La validation biologique de ces nouveaux anticorps anti-P2Y6R et NTS1R sera réalisée à l’aide de techniques de biologie cellulaire et moléculaire (génération de lignée cellulaire surexprimant les récepteurs d’intérêts, analyse par Western blot, immunofluorescence, ELISA, FACS et spectrométrie de masse) et seront appliquées à des préparations de culture cellulaire et de tissues isolés de différents modèles murins. Finalement, le candidat procèdera, en collaboration avec les équipes en place, aux essais fonctionnels des nouveaux anticorps à l’aide de modèles murins récapitulant le cancer colorectal humain et de tissus provenant d’une biobanque de CCR. Ce projet de recherche appliquée en étroite collaboration avec une Biotech permettra au candidat de toucher à divers aspect du développement de nouvelles molécules ayant un fort potentiel de translation vers l’humain. La codirection des travaux de recherche et les interactions avec IBio seront une occasion unique d’interagir et d’apprendre de nouvelles approches expérimentales, mais aussi d’être dans un environnement compétitif et d’apprécier les impératifs de la recherche en compagnie.

Profil recherché : Nous sommes à la recherche de deux (2) candidats(es) dynamiques, qui n’ont pas peur des nouveaux défis et qui doivent s’adapter facilement au travail d’équipe puisqu’il y aura collaboration avec les équipes de recherche des Prs Gendron, Sarret et celle de IBio. Les candidats(es) devront être titulaires d’un doctorat en biochimie, biologie cellulaire ou immunologie d’une université reconnue. Les candidats(es) recherchés doit être capables de s’exprimer et écrire en anglais et idéalement avoir une connaissance fonctionnelle du français.

Les candidats(es) intéressés doivent faire parvenir leur candidature à Fernand-P.Gendron@USherbrooke.ca 

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Groupe de recherche : Prs Fernand-Pierre Gendron et Philippe Sarret (co-directeurs) ainsi que Pr Eric Marsault et Immune Biosolutions inc. (collaborateurs).

Lieu de travail : Institut de Pharmacologie de Sherbrooke (IPS) et Pavillon de recherche appliquée sur le Cancer (PRAC)

Subvention : Fonds Merck Sharpe & Dohme de la Faculté de médecine et des sciences de la santé de l’Université de Sherbrooke, MITACS et Créneau Accord (MEIE)

Titre du projet : Élaboration d’une nouvelle génération d’anticorps anti-RCPG pour le diagnostic et le traitement du cancer colorectal

Projet : Le cancer colorectal (CCR) est la deuxième cause de mortalité due au cancer au Canada. Malgré des années de recherche, ce cancer est encore mal diagnostiqué et les traitements utilisés manquent de sélectivité. Les récepteurs couplés aux protéines G (RCPGs) sont la cible d’environ 40 % des médicaments actuellement disponibles et ont récemment été identifiés comme de nouvelles cibles dans le traitement des cancers. L’absence d’outils valides permettant d’identifier l’expression endogène des RCPGs ou encore de moduler sélectivement leurs activités a grandement ralenti l’utilisation de cette famille de récepteurs pour le diagnostic et le traitement des cancers, incluant le CCR. Ce projet vise donc à développer et valider une nouvelle approche basée sur l’utilisation de peptides macrocycliques comme épitopes conformationnels mimétiques (MEM) pour produire des anticorps fonctionnels contre deux récepteurs couplés aux protéines G (NTS1R et P2Y6R) d’intérêt dans le diagnostic et le traitement du cancer colorectal.

L’étudiant(e), sous la co-supervision des Prs F.P. Gendron et P. Sarret, aura comme projet de procéder à la validation biologique des nouveaux anticorps développés. Pour y parvenir, différentes techniques de biologie cellulaire et moléculaire (génération de lignée cellulaire surexprimant les récepteurs d’intérêt, analyse par Western blot, immunofluorescence, ELISA, FACS et spectrométrie de masse) seront appliquées à des préparations de culture cellulaire et de tissus isolés de différents modèles murins. Finalement, l’étudiant(e) procèdera, en collaboration avec les équipes en place, aux essais fonctionnels des nouveaux anticorps à l’aide de modèles murins récapitulant le cancer colorectal humain et de tissus provenant d’une biobanque de CCR.

Ce projet de recherche appliquée permettra à l’étudiant(e) de toucher à divers aspects du développement de nouvelles molécules ayant un fort potentiel de translation vers l’humain. La codirection des travaux de recherche et les interactions avec Immune Biosolutions inc. (IBio) seront une occasion unique d’interagir et d’apprendre de nouvelles approches expérimentales, mais aussi d’être dans un environnement compétitif et d’apprécier les impératifs de la recherche en compagnie.

Profil recherché : Nous sommes à la recherche d’un étudiant(e) dynamique, qui n’a pas peur des nouveaux défis et qui doit s’adapter facilement au travail d’équipe puisqu’il aura à collaborer avec les équipes de recherche des Prs Gendron et Sarret, mais aussi avec celles des collaborateurs. L’étudiant(e) recherché(e) aura de préférence une excellente formation en biochimie/biologie cellulaire, une bonne aptitude pour la manipulation d’animaux, et une connaissance des concepts d’immunologie.

Les étudiants intéressés doivent faire parvenir leur candidature à Fernand-P.Gendron@USherbrooke.ca

 

Vienna

Postdoctoral/senior scientist position available in the field of Pain Research

Job description:

The Center of Brain Research, Medical University of Vienna, is an internationally leading research institution in neuroscience. We offer a vibrant academic environment, outstanding career development plans as well as competitive salaries and social benefits in Vienna, Austria, the city with the world`s best quality of living (Mercer Quality of Living, 2015). The present recruitment notice is from the Department of Neurophysiology headed by Jürgen Sandkühler.

The primary focus of the laboratory is on central mechanisms of pain generation, amplification and therapy, see Nat Rev Neurosci 15 (2014) 43Science 335 (2012) 235Science 325 (2009) 207Science 312 (2006) 1659.

We offer 5 year contracts and tenure track options for highly competitive neuroscientists with a PhD degree in a relevant discipline and strong background in at least one of the following fields:

  • optogenetics and pharmacogenetics
  • two-photo laser-scanning microscopy
  • in vitro and in vivo neurophysiology
  • behavioural assays

Please visit our website for further information http://cbr.meduniwien.ac.at/organisation/dept-neurophysiology/home. Starting dates are open and flexible. The call is open until the position is filled. Please send requests and applications to: juergen.sandkuehler@meduniwien.ac.at or call +43-1-40160-34101.
Start of the position: flexible
Limited till:
Department: Department of Neurophysiology
Contact: Univ.Prof. Dr. Jürgen Sandkühler

 

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Postdoctoral/Research Fellow

Job Description:

Immediate job opening for a Postdoctoral Fellow position within the Department of Anesthesiology, Perioperative, and Pain Medicine at Stanford University School of Medicine, Palo Alto, CA. Candidates should have a background in neuroscience or related field relevant to the study of chronic pain. The position is funded for 2-3 years by a recently awarded DOD project focused on pain associated with traumatic brain injury (TBI). The project focuses on the investigation of the involvement of lipid mediators in pain and cognitive dysfunction following TBI and explores the potential of monoclonal antibodies directed toward those mediators.  Should these experiments prove successful, translation to the clinic is highly likely. We will be using a lateral fluid percussion model of TBI in rats; behavioral and gene expression sequelae to TBI and test compound administration will be assessed over time.  Additional studies will use positron emission tomography methods to examine biochemical changes in vivo induced by TBI as well as by treatments. Prior training with animal behavioral pharmacology, fluorescent microscopy and standard biochemical techniques (e.g, RT-PCR, western blot, ELISA) are essential; experience with animal imaging methods are preferred.

This position requires an individual with strong reading and writing skills, interpersonal communication skills and the ability to work independently as well as on a team. The successful candidate will become a part of an interdisciplinary and collaborative group of preclinical and clinical research faculty at Stanford focused on translational pain research.

For more information please contact Dr. David C. Yeomans, Director of Pain Research, Department of Anesthesiology, Perioperative, and Pain Medicine, 300 Pasteur Drive, Stanford University, Stanford, CA  94305-5117. Email: dcyeomans@stanford.edu. Interested applicants should provide (i) a brief statement of research experience and career goals, (ii) C.V. and (iii) the names of three references.

Postdoctoral Fellow

Principal Duties and Responsibilities:

  • Investigation of the involvement of lipid mediators, focusing on Lysophosphatidic acid (LPA) in the pathophysiology of traumatic brain injury.
  • Perform surgical preparation and brain injury in rats using the lateral fluid percussion model.
  • Assess behavioral effects of TBI using standard and novel indices.
  • Assess expression levels of LPA and markers of neural inflammation in brain using immunofluorescence microscopy and ELISA.
  • Determine efficacy of application of humanized monoclonal antibody directed toward LPA on sequelae to TBI
  • Contribute to PET imaging studies examining biochemical effects of TBI with or without antibody treatment.
  • Strong reading and writing skills, interpersonal skills and work on a team as a part of an interdisciplinary and collaborative group of preclinical and clinical research faculty at Stanford focused on translational pain research.
  • Supervise technicians, graduate students and medical students

 

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A postdoctoral research associate / scholar position is available in the Washington University Pain Center at Washington University School of Medicine in St. Louis.  Dr. Jose Moron-Concepcion is seeking a highly motivated individual to pursue studies focused on defining (1) the roles of glutamate receptors in the mechanisms underlying opioid-induced synaptic plasticity, and (2) the mechanisms underlying opioid dependence and relapse to drug-seeking behavior.   The research program involves a combination of electrophysiological, behavioral models of drug dependence, live cell imaging and molecular-genetic approaches. This position also provides the opportunity to gain expertise in molecular physiology and the determination of the role of glutamate and ion channels in the mechanisms underlying opioid-induced synaptic plasticity. In addition, this project will allow the development of imaging skills with epifluorescence and confocal microscopy.  The focus will be on the professional growth and development necessary to transition to an independently-funded faculty researcher.

Required Qualifications

The ideal candidate should hold a Ph.D. or M.D./Ph.D. degree, possess a strong background in cellular electrophysiology, particularly the field recordings and  whole-cell voltage-clamp techniques, and the analyses of electrophysiological data. In addition, experience with behavioral animal models of dependence (conditioned place preference, i.v. self-admin, etc.) is highly desirable. Experience/publications using the whole-cell variation of the patch-clamp technique and behavioral models of drug dependence.
Preferred Qualifications

* Prior experience with surgical procedures in rodents for intracranial administration of drugs is preferred.
* Experience with fluorescent imaging in single cells with either or both epifluorescence microscopy and/or confocal microscopy preferred.
* Experience working with glutamate receptors (AMPAR, NMDAR, mGluARs) is preferred.
* Completed or currently completing post-doctoral fellowship position.
Salary will be based on NIH guidelines.

Applicant Special Instructions

Applicants should send a cover letter with a brief statement of research experience and interests along with curriculum vitae and three letters of recommendation to: Jose Moron-Concepcion, PhD, Associate Professor of Anesthesiology, Washington University School of Medicine; jmc@anest.wustl.edu

EOE Statement

All qualified applicants will receive consideration for employment without regard to sex, race, ethnicity, protected veteran, or disability status.

 

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Postdoctoral Scientist Position Available – Neurodegeneration

University of Kentucky, Sanders-Brown Center on Aging Lexington, Kentucky, U.S.A.

Principal Investigator: Linda Van Eldik, PhD. A postdoctoral scientist position is available immediately at the University of Kentucky, Lexington KY. The position is in the Sanders-Brown Center on Aging, an established research center in aging and dementia where independent basic and clinical scientists work in a collaborative environment. The Center on Aging also includes the NIH-funded Alzheimer’s Disease Center that provides unique and outstanding resources to support innovative research (e.g. longitudinally followed and well-characterized clinical cohorts, neuroimaging, biomarkers, autopsy specimens). The Center on Aging collaborates with a number of other centers at the university that facilitate neuroscience research, including the Spinal Cord and Brain Injury Research Center, the Magnetic Resonance Imaging and Spectroscopy Center, and the Center for Clinical and Translational Science.

The successful candidate will benefit from an experienced mentor, a stimulating and collaborative research environment, and an organized training plan. There are ample opportunities for scientific growth, career enhancement, and development into an independent investigator in academia, industry, or other career paths. Although the project is currently funded by NIH, an integral part of postdoctoral training is the process of preparing a research proposal and writing a fellowship application, so postdocs are encouraged to apply for external funding when possible. Recent postdocs in the lab have been successful at obtaining NIHfunded F32 and K99/R00 awards, which provides recognition for both the fellow and the Center on Aging.

We seek a highly motivated, creative, and collaborative individual to work on mechanistic and translational research projects focused on the detrimental inflammatory and neurodegenerative responses that contribute to pathophysiology in mouse models of CNS disorders, especially traumatic brain injury (TBI) and Alzheimer’s disease (AD). One project is defining the role of the stress-related kinase, p38α MAPK, in regulating the TBI-induced up-regulation of proinflammatory molecules that lead to disease-relevant neuropathology and behavioral impairments. Through the use of novel mouse models and CNS-penetrant experimental therapeutics, we are defining when, where and how p38α MAPK can be targeted for beneficial outcomes.

Requirements: PhD or MD/PhD in an area relevant to pharmacology or neuroscience. Must have excellent interpersonal, organizational, verbal and written communication skills, a solid publication record, and appropriate experience. Preference will be given to individuals with experience in one of the following areas: inducible conditional knockout mouse models, mouse neuropathology and behavior, primary glia/neuron cell culture, gene expression profiling, pharmacological modulation of glia signaling pathways. Prior experience in AD, TBI, or related neurological disease research is also desirable.

Applicants should send an email that includes a cover letter with a brief statement of research experience and career goals, a curriculum vitae, and names and contact information for three references to Dr. Linda Van Eldik, linda.vaneldik@gmail.com The University of Kentucky is an equal opportunity employer and encourages applications from minorities and women.

UNE

Pr Geoffrey Bove, DC, PhD from University of New England is looking for a postdoctoral fellow to help further develop his interests on the effects of inflammation on nociceptor axons.  His main goals require teased fiber recordings, in-vivo and ex-vivo, in rats and mice, which Pr Bove will teach hands-on.

To this end, beyond scientific acumen and interest, very high levels of eye-hand coordination and patience are the main prerequisites.  (Not kidding — experience as a watchmaker or similar skill would be given high consideration!)
Contact Pr Geoffrey Bove, DC, PhD
11 Hills Beach Rd., Stella Maris 102/103, Biddeford, ME 04005
Email: gbove@une.edu
Website: http://www.une.edu/faculty/profiles/geoffreybove.cfm

 

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A postdoctoral fellow position sponsored by NIH grants is immediately available at the Department of Anesthesia, Harvard Medical School/BIDMC in Boston, MA to study mechanisms underlying the genesis of migraine and post-traumatic headaches. The project involves in vivo recording from trigeminal nociceptors in rodents together with the use of optogenetic and chemogenetic methods.

The applicant should have a Ph.D. in neuroscience, pharmacology or physiologyand extensive experience with in vivo extracellular electrophysiology. Knowledge of immunohistochemistry is also preferred. The applicant should be able to work independently and demonstrate English speaking fluency.

Salary will be commensurate with current NIH/NRSA guidelines. Qualified applicants should email a one-page description of career goals, contact information of up to three references and a current CV to: Dr. Dan Levy: dlevy1@bidmc.harvard.edu

 

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Postdoctoral Position Pain and Translational Symptom and Science

The Department of Pain and Translational Symptom Science at the University of Maryland, Baltimore invites applications for a Post-doctoral position to join Dr. Luana Colloca’s laboratory.
Our research focuses on the mechanisms of placebo effects, pain genetics and genomics, pain perception and modulation. We combine approaches ranging from psychophysiology to brain mapping, from genetics to computational neuroscience exploring pain mechanisms in healthy subjects as well as patients suffering from pain disorders.

The candidate should have a strong background in neuroscience and/or psychology with a record of successful publications in the fields of pain, genetics, brain mapping (EEG, MEG, and fMRI) and/or computational neuroscience. Preference will be given for applicants with the following experience: 1) familiarity with running experimental pain model studies; 2) analysis of EEG and fMRI data; and 3) Programming skills in Matlab.

Appointments and salary are commensurate with research experience and accomplishments following NIH guidelines:
http://grants.nih.gov/grants/guide/notice-files/NOT-OD-14-046.html

The successful applicant will be part of a vibrant research program focusing on the neurobiology of pain experience and pain modulatory systems. Collaboration with faculty in the department as well as with scientists/clinicians in other departments and the UMB Center for the Advancement of Chronic Pain Research (CACPR) is strongly encouraged.

Please send a cover letter, CV, statement of research and career objectives, and contact information for 3 references (all in one file) to: Dr. Luana Colloca.

Review of applications will begin March 15, 2015 and continue until the position is filled.
Luana Colloca, MD, PhD University of Maryland Baltimore SON Pain and Translational Symptom Science UM Center to Advance Chronic Pain Research 655 West Lombard Street Baltimore, MD 21201 colloca@son.umaryland.edu

 

ISIS PHARMACEUTICALS, INC. LOGO

Isis Pharmaceuticals, Inc., located in the North San Diego County city of Carlsbad, was founded in 1989 to create advanced, novel medicines to treat complex and challenging diseases. We are the pioneer in the discovery and development of antisense drugs with more than 1600 patents.

Isis is a challenging, motivating and rewarding environment designed to foster innovation and scientific excellence. Our founding goals have changed little in over 20 years and our success is a direct result of our outstanding employees. We are interested in bringing together individuals with different skill sets into this creative environment to be part of a productive team. Join us and experience our unique culture while you develop and expand your career.
POST DOCTORAL FELLOW, NEUROSCIENCE DRUG DISCOVERY
We are seeking a highly motivated and talented individual to join our neuroscience drug discovery group as a Postdoctoral Fellow. The selected candidate will work with a multi-disciplinary team of researchers in a fast paced environment. The emphasis will be to broaden our understanding of antisense oligonucleotides in the pain system, and to expand our pain drug discovery programs through use of primary cell culture and model systems. The successful candidate will have a strong work ethic and background in pain research, an interest in drug discovery and working collaboratively, and the ability to independently design and execute experiments.

REQUIREMENTS:

  • A Ph.D. in Neuroscience or similar field, with less than 3 years post doctoral experience.
  • Strong background molecular mechanisms of pain is required
  • Prior experience in primary neuron and glial cell culture is preferred
  • Experience with rodent surgeries and rodent models of acute and neuropathic pain is preferred
  • Proficiency in molecular biology is preferred
  • Track record of innovative research and scientific publications
  • Excellent organizational, interpersonal and oral communication skills
  • An ability to be productive and successful in an intense work environment
  • Must be able to begin work no later than June 1, 2015

Excellent salary and benefits package offered.
For more information on Isis and to apply for this position, please visit our website, www.isispharm.com. Reference Requisition # 15-0003
NO PHONE CALLS PLEASE. PRINCIPALS ONLY.

 

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Research Associate, PostDoc Fellow, or Assistant Scientist are available immediately in the Department of Anesthesiology at the University of Miami Miller Medical School.

Our research focuses on the mechanisms of neuropathic pain and/or opioid abuse with gene therapy supported by the NIH funded projects.

The positions open to recent PhD and/or MD with background in neuropharmacology, neuroscience, molecular biology, histology/imaging or a related discipline. Priority to applicants with skills of strong molecular biology, gene cloning, or rat/mouse Brain stereotaxic surgery is given. Applicants with Master degree and strong background related to this research skill are also available.

Send your CV and the names of referees to: Dr. Hao, Department of Anesthesiology, University of Miami, Miami, FL 33136. Email: shao@med.miami.edu

mcgill-university-logo

Graduate Student/Postdoctoral Positions in Electrophysiology

Two CIHR-funded positions are available immediately for enthusiastic graduate students and/or postdoctoral fellows with a keen interest in using electrophysiology and imaging techniques to study ligand-gated ion-channels and their role in neuronal circuit behavior.

The first project will focus on an ongoing theme to understand the structure-function properties of ionotropic glutamate receptors. The successful applicant will use single-channel and macroscopic patch clamp techniques to tease apart the mechanism of channel activation in wildtype and mutant receptors. This work will be part of a multilab collaboration with researchers using computational chemistry and structural biology.

The second project will examine the signaling defects associated with Fragile X syndrome, a prominent neurodevelopmental disorder. The successful applicant will study neuronal circuit connectivity using single and multi-electrode recordings from acutely isolated brain tissue. Imaging and functional experiments will be collected simultaneously using a multiphoton microscope equipped with an electrophysiology rig.

Related Publications

Dawe et al (2013) Defining the structural relationship between kainate receptor deactivation and desensitization. Nat Struct Mol Biol. 20(9):1054-61

Accardi et al (2014) Mitochondrial reactive oxygen species regulate the strength of inhibitory GABA-mediated synaptic transmission. Nat Commun. 5:3168 doi: 10.1038/ncomms4168

*Student stipends will be based on the policy recommendations of individual McGill Graduate Programs. Postdoctoral salaries will be based on CIHR recommendations and level of experience*

McGill University is one of Canada’s leading post-secondary institutions with the main campus located in the heart of the lively downtown area of Montreal. McGill attracts students and researchers from more than 150 countries around the world. Almost half of McGill students claim a first language other than English with more than 6,800 international students making up almost 20 per cent of the student body.

Applicants should send a cover letter, cv and the names of 2-3 referees to:

Dr. Derek Bowie,

Department of Pharmacology & Therapeutics

McGill University, Faculty of Medicine

3649 Promenade Sir-William Osler, Rm 164

Montreal, QC, Canada, H3G 0B1

Tele: 514-398-1581 Email: derek.bowie@mcgill.ca

Webpage: http://www.medicine.mcgill.ca/pharma/dbowielab

 

facmedcol

Eyes High Post-doctoral Fellowship in Pain Research Area: Neuroscience (Pain research) Duration: Minimum 2 years Start Date: 2014 (negotiable) Salary: $50,000/year plus medical benefits

The Department of Comparative Biology & Experimental Medicine at the University of Calgary is accepting applications for an Eyes High Post-doctoral Scholar in the laboratory of Dr. Tuan Trang. The position is funded by the University’s Eyes High rising stars strategy (http://www.ucalgary.ca/risingstars/postdoc), which targets candidates of the highest caliber and that are competitive for national or international fellowships.

Job Description

The Post-doctoral Scholar will examine the fundamental molecules and processes involved in chronic pain and the association with stress/anxiety. The scholar will dissect the inner workings of microglia which are immune cells in the brain and spinal cord causally implicated in chronic pain signaling. Responsibilities include being the primary person generating data, analyzing, graphing and presenting results, writing and submitting manuscripts. The scholar will be expected to generate new ideas in collaboration with the Principle Investigator. On a daily basis the scholar will interact with other laboratory personnel, train graduate and undergraduates and is expected to be an energetic member of the Hotchkiss Brain Institute.

Qualifications

Candidate must have a PhD in Neuroscience, Cell Biology, or a related discipline. The candidate will have technical expertise in biochemical, molecular, and imaging approaches. The candidate must also have a track record of academic success as evidenced by peer-reviewed publications, awards, and scholarships.

Application Details

Interested applicants please provide: 1) a cover letter with statement of research experience and interests, and 2) curriculum vitae. Deadline for application is October 31, 2014. Submit applications via email to trangt@ucalgary.ca.

Visit http://www.ucalgary.ca/tranglab/ for an overview of the laboratory.

About the University of Calgary

The University of Calgary is a leading Canadian university located in the nation’s most enterprising city. The university has a clear strategic direction to become one of Canada’s top five research universities by 2016, where innovative teaching and groundbreaking research go hand in hand, and where we fully engage the communities we both serve and lead. The strategy is called Eyes High, inspired by our Gaelic motto, which translates to ‘I will lift up my eyes.’ To succeed as one of Canada’s top universities, where new ideas are created, tested and applied through first-class teaching and research, the University of Calgary needs more of the best minds in our classrooms and labs. We’re increasing our scholarly capacity by investing in people who want to change the world, bringing the best and brightest to Calgary to form a global intellectual hub and achieve advances that matter to everyone. About Calgary Named a cultural capital of Canada and one of the best places to live in the world, Calgary is a city of leaders – in business, community, philanthropy and volunteerism. Calgarians benefit from the strongest economy in the nation and enjoy more days of sunshine per year than any other major Canadian city. Calgary offers many cultural and sporting amenities, and is located near the Rocky Mountains, Banff National Park, and Lake Louise, which boast unparalleled skiing and hiking.

 

UCSF-logo

Ion Channel Pharmacologist

We are seeking a highly motivated postdoctoral electrophysiologist who has experience in patch-clamp analysis of ion channels, to join multidisciplinary NIH-funded research team investigating role of ion channels in DRG neurons, in the development of neuropathic and chronic pain (e.g. see PubMed ID: 22704965, 23831864).

Experience with culturing DRG neurons, voltage- and current-clamp analysis and calcium imaging are required. You will be expected to conduct independent research, as well as work collaboratively within a highly productive, interactive multi-disciplinary team that includes molecular biology, biochemistry and behavior.

Send statement of interest, curriculum vitae, and three names of reference to Jon D. Levine (Jon.Levine@ucsf.edu).

 

University_of_Texas--Dallas_TX_391992

Postdoctoral Position in Mechanisms and Therapeutics for Chronic Pain in Dallas, Texas

Gregory Dussor and Theodore Price are seeking multiple postdoctoral fellows to conduct research on molecular mechanisms of chronic pain in preclinical models ranging from migraine to neuropathic pain. These NIH-funded postdoctoral fellowships are in the School of Behavioral and Brain Sciences at The University of Texas at Dallas (UTD — bbs.utdallas.edu). UTD is the fastest growing University in Texas, is ranked number 3 in the nation among Universities less than 50 years old and houses a vibrant neuroscience research community. The city of Dallas is an international economic hub with a vibrant cultural atmosphere and world-class sports and entertainment in a temperate climate.

Candidates must have a Ph.D. in Neuroscience, Pharmacology or a related scientific discipline and training in at least one of the following: patch-clamp electrophysiology, confocal microscopy, cellular signaling or behavioral pharmacology. A strong record of research productivity is expected. The successful candidate will be a highly motivated individual wanting to bring an existing skill set to a diverse laboratory where scientific problems are approached from multiple directions with advanced methodologies. Excellent command of verbal and written English is required for the position.

Applicants interested in the open positions should send their CV, a brief statement of research interest and contact information for two references to either Dr. Theodore Price (Theodore.price@utdallas.edu) or Dr. Gregory Dussor (Gregory.dussor1@utdallas.edu). UTD is an equal opportunity employer.

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